Leonard Gordon Wolfson, Baron Wolfson, FRS (11 November 1927 – 20 May 2010) was a British businessman, the former chairman of GUS, and son of GUS magnate Sir Isaac Wolfson, 1st Baronet. He is the father of Janet Wolfson de Botton.

He attended The King's School, Worcester from 1942 to 1945.

Having been knighted in 1977, he was created a Life Peer on 13 June 1985 with the title Baron Wolfson, of Marylebone in the City of Westminster. He was a member of the Conservative Party. On the death of his father in 1991, Lord Wolfson succeeded as 2nd Baronet (styled "of St Marylebone in the County of London"). He was granted a leave of absence from the House of Lords from 2008.

He was Chairman of the Wolfson Foundation. He was elected an Honorary Fellow of the British Academy in 1986, and an Honorary Fellow of the Royal Society in 2005. He was also an Honorary Fellow of three Oxford colleges, Wolfson College (named after his father Isaac Wolfson), St Catherine's College, and Worcester College.

He died on 20 May 2010.

Lord Wolfson was a philanthropist, supporting many causes: he was president of the Jewish Welfare Board, and a trustee of the Imperial War Museum. The Lord Leonard and Lady Estelle Wolfson Foundation was set up in 2012, and continues to support scientific and medical research, education and the arts.